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. 2020 Feb 28;2020(2):CD001168. doi: 10.1002/14651858.CD001168.pub3

Liu 2013.

Methods Study design: RCT
Conducted in West China
Number of centres: 1 (Hospital of Stomatology, Sichuan University)
Recruitment period: April 2011 to May 2012
Funding source: unspecified
Participants Inclusion criteria: erosive OLP determined clinically and pathologically, aged 18–60 years; single erosive lesion; erosive area 100 mm²; disease process duration < 2 months; normal physical examination results before medication (including complete blood cell count, blood glucose test, renal and hepatic clinical chemistry examination, blood pressure examination, ultrasonic examination of abdomen, chest x‐ray and electrocardiogram)
Exclusion criteria: > 1 site of erosion (e.g. people with bilateral erosions); hypertension (stage 2), cardiovascular disease, blood disease, or other systemic diseases; other oral mucosal diseases; immunotherapy within 3 months or other topical or systemic treatment of OLP within 1 week of the start of the study; lichenoid reaction caused by amalgam fillings or certain drugs; pregnancy or intention of pregnancy; breastfeeding; use of steroid hormone‐based contraceptives recently; refusal to follow the doctor's advice or to complete the follow‐up review
Group A: randomised 30; analysed 29
Group B: randomised 31; analysed 30
Interventions Group A: betamethasone compound 1.4 mg (betamethasone dipropionate 5 mg + betamethasone disodium phosphate 2 mg/mL), intralesional injection, once weekly for 2 weeks
Group B: triamcinolone acetonide 8 mg, intralesional injection, once weekly for 2 weeks
Outcomes Pain (VAS), size of erosive area, relapse rate, adverse effects
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "Participants were assigned randomly to the experimental and control groups using a computer‐generated random number list."
Allocation concealment (selection bias) Unclear risk Comment: insufficient information to permit judgement.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Quote: "All injections were performed by the same researcher, who was the only researcher aware of which participants received which medication."
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Comment: participants (self‐assessed, pain was primary outcome) were not blinded.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: missing data balanced in numbers across intervention groups (1 in each) and not likely to have a clinically relevant impact on the intervention effect estimate. Unlikely to have introduced bias.
Selective reporting (reporting bias) Low risk Planned outcomes reported.
Other bias Low risk No other sources of bias identified.