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. 2020 Feb 21;11:123. doi: 10.3389/fphar.2020.00123

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Copyright © 2020 Tian, Wang, Tang, Li, Liu, Chu and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antagonistic effects of tempol on the pro-pyroptotic action of ATO (2 μM)/AA (2 mM) combination in SW620 cells. (A) Tempol (1 mM) abolishes the elevation of caspase-1 protein level induced by ATO (2 μM)/AA (2 mM) combination treatment. The data are represented as mean ± SEM (n = 5). *P < 0.05, vs. Ctl; ^# P < 0.05 vs. AA + ATO. (B, C) Tempol (1 mM) mitigated the increased mRNA levels of IL-1β and IL-18 induced by ATO/AA combination treatment. The data shown are mean ± SEM of three independent experiments. **P < 0.01, vs. Ctl. ***P < 0.001 vs. Ctl; ^### P < 0.001 vs. AA + ATO.