Skip to main content
. 2020 Feb 21;11:288. doi: 10.3389/fimmu.2020.00288

Figure 2.

Figure 2

Expansion of plasmablasts in patients with Hashimoto's thyroiditis. (A) HSNE-embedding depicting the local probability density of CD19+ B cells (upper first left) and the subsets defined by Gaussian mean-shift clustering (lower first left). Relative expression of selected markers in embedded CD19+ B cells. (B) Heatmap showing ArcSinh5-transformed median expression of relevant markers within the clusters identified in (A). The dendrogram depicts hierarchical clustering of subsets. (C) Frequency of plasmablasts (#16) in healthy controls (HC, n = 15) and patients with new-onset (N-T1D, n = 7) and long-standing (L-T1D, n = 9) type 1 diabetes, Hashimoto's thyroiditis (HT, n = 8), Graves' disease (GD, n = 7) and autoimmune Addison's disease (AD, n = 8). Dots represent individual samples and bars indicate median. One-way ANOVA with Tukey's test for multiple comparisons, *p < 0.05 and **p < 0.01. HSNE, hierarchical stochastic neighbor embedding.