Table 1.
Descriptive data of cohort groups.
| Parameter | HC (n = 15) | N-T1D (n = 7) | L-T1D (n = 9) | HT (n = 8) | GD (n = 7) | AD (n = 8) |
|---|---|---|---|---|---|---|
| Age (yr) | 28.9 ± 1.5 | 23.3 ± 1.0 | 34 ± 2.9 | 32 ± 2.9 | 34.4 ± 3.6 | 36.3 ± 2.5 |
| Sex (M/F) | 7/8 | 5/2 | 5/4 | 2/6 | 2/5 | 6/2 |
| Disease duration (yr) | NA | 0.3 ± 0.03 | 19.1 ± 2.4 | 4.2 ± 1.0 | 0.5 ± 0.13 | 6.3 ± 1.8 |
| BMI (18.5–25 kg/m2) | 22.9 ± 0.7 | 21.1 ± 0.6 | 26.2 ± 1.4 | 24.3 ± 1.1 | 26.7 ± 1.8 | 25.4 ± 1.6 |
| Creatinine (60–105 μmol/L) | 74.8 ± 3.4 | 65.0 ± 5.2 | 70.5 ± 3.2 | 67.0 ± 2.0 | 65.4 ± 4.7 | 85.5 ± 4.1 |
| F-Glucose (4.0–6.0 mmol/L) | 5.6 ± 0.1 | 11.3 ± 2.0 | 11.2 ± 1.0 | 5.9 ± 0.2 | 5.4 ± 0.3 | 5.2 ± 0.2 |
| HbA1c (27–42 mmol/mol) | 31.7 ± 0.6 | 75.4 ± 11.0 | 59.2 ± 3.0 | 32.5 ± 1.0 | 30.9 ± 1.4 | 32.9 ± 0.9 |
| TSH (0.4–4.0 mIE/L) | 1.9 ± 0.2 | 3.8 ± 1.0 | 2.3 ± 0.2 | 5.9 ± 2.4 | 1.0 ± 0.8 | 3.0 ± 0.4 |
| T3 (3.1–6.8 pmol/L) | 5.1 ± 0.1 | 5.4 ± 0.1 | 4.8 ± 0.2 | 4.5 ± 0.2 | 5.8 ± 1.2 | 6.3 ± 0.3 |
| T4 (12.0–22.0 pmol/L) | 15.6 ± 0.4 | 15.2 ± 0.8 | 15.0 ± 0.4 | 16.0 ± 0.9 | 20.4 ± 2.4 | 16.3 ± 1.0 |
| S-Cortisol (220–650 nmol/L) | 541 ± 71 | 497 ± 136 | 466 ± 25 | 425 ± 27 | 341 ± 27 | 526 ± 64 |
Age, sex distribution, disease duration, BMI and clinical parameters at the time of sampling were assessed in healthy controls (HC) and patients with new-onset (N-T1D) and long-standing (L-T1D) type 1 diabetes, Hashimoto's thyroiditis (HT), Graves' disease (GD), and autoimmune Addison's disease (AD). Normal ranges for clinical parameters are described (first column). All values are given as mean ± SEM. F, female; HbA1c, glycated hemoglobin; M, male; TSH, thyroid-stimulating hormone; T3, free triiodothyronine; T4, free thyroxine; yr, years.