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. 2020 Jan 22;6(2):197–206. doi: 10.1021/acscentsci.9b01076

Figure 4.

Figure 4

Tdh- and tRNA synthetases-derived origins of AI-3 analogs. (A) Results for in vitro synthesis of linear-1 by isolated MetRS. MetRS, AMB, l-Met, and ATP are required for the in vitro synthesis of linear-1. (B) Time-course analysis results of linear-1 production from in vitro assays. (C) Proposed biosynthesis of pyrazinones 1–7 and pyrazine 11. (D) Biosynthetic pathway of pyrazinone 6 and pyrazine 11. Taut., tautomerization. n = 3 biological replicates. Data are mean ± SD. nd, not detected.