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. 2020 Feb 21;11:240. doi: 10.3389/fimmu.2020.00240

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Copyright © 2020 Huda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms for therapeutic depletion of B cells. Therapeutic antibodies mediate their cytotoxic effects by four possible mechanisms. Cross-linking of mAb to B cell surface antigen (A) blocks ligand binding of essential receptors that mediate B cell survival (direct apoptosis), (B) triggers engagement of effector cells through recognition of its Fc sequence, and subsequent phagocytosis by effector cells (ADCP), (C) lysis by granzymes secreted from effector cells (ADCC), or (D) activates the complement cascade and lysis by C3 deposits and MAC formation on the cell surface.