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. 2020 Feb 21;10:184. doi: 10.3389/fonc.2020.00184

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Copyright © 2020 Han, Zhang, Wang, Ji, Cao, Qin, Yu, Huang and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hsa_circ_0021087 promotes GC cell proliferation in vitro experiments. (A) Hsa_circ_0021087 expression level was downregulated in GC cells (SGC-7901, MGC-803 and BGC-823) compared with the normal cell GES1. (B) Hsa_circ_0005051 was also downregulated in the GC cell lines. (C) Following the transfection of MGC-803 and BGC-823 cells with specifically synthesized small interference RNA and OE-hsa_circ_0021087, the expression of hsa_circ_0021087 in cells was analyzed by reverse transcription-quantitative PCR. (D,E) The Cell Counting Kit-8 assay indicated that hsa_circ_0021087 promoted MGC-803 and BGC-823 cell proliferation. (F–H) Wound healing assays were performed on MGC-803 and BGC-823 cells treated with si-NC, si-circ_0021087 and OE-circ_0021087. (I–K) Transwell chambers were used to perform cell migration assays in MGC-803 and BGC-823 cells. *P < 0.05, **P < 0.01, and ***P < 0.001. GC, gastric cancer.