Table 2.

Univariable and multivariable Cox regression analyses in each data set

Variables	Univariable modela			Multivariable modela
	HR	95% CI of HR	P valueb	HR	95% CI of HR	P valueb
GSE39582 training (N = 278)
Seven-lncRNA risk score	2.71	2.087–3.519	< 0.001	2.749	2.111–3.579	< 0.001
Age	0.999	0.983–1.014	0.877	1.01	0.993–1.027	0.261
Gender	1.457	0.951–2.233	0.084	1.428	0.925–2.205	0.108
TNM stage I	1.00(referent)			1.00(referent)
TNM stage II	10,245,861	0.000-	0.994	5,864,621	0.000-	0.995
TNM stage III	16,355,014	0.000-	0.993	7,823,016	0.000-	0.994
TNM stage IV	52,014,059	0.000-	0.993	42,817,026	0.000-	0.994
GSE39582 validation (N = 274)
Seven-lncRNA risk score	1.978	1.558–2.511	< 0.001	1.875	1.435–2.449	< 0.001
Age	1	0.984–1.016	0.977	0.998	0.982–1.015	0.839
Gender	1.117	0.73–1.709	0.609	1.559	0.996–2.442	0.052
TNM stage I	1.00(referent)			1.00(referent)
TNM stage II	4.42	0.598–32.673	0.145	3.223	0.434–23.944	0.253
TNM stage III	10.644	1.465–77.354	0.02	5.997	0.808–44.512	0.08
TNM stage IV	48.847	6.533–365.212	< 0.001	40.881	5.415–308.664	< 0.001
Entire GSE39582 (N = 552)
Seven-lncRNA risk score	2.263	1.907–2.685	< 0.001	2.248	1.879–2.69	< 0.001
Age	0.999	0.988–1.011	0.927	1.004	0.992–1.015	0.538
Gender	1.278	0.946–1.726	0.110	1.536	1.132–2.084	0.006
TNM stage I	1.00(referent)			1.00(referent)
TNM stage II	7.479	1.036–53.984	0.046	4.652	0.642–33.689	0.128
TNM stage III	14.37	1.999–103.274	0.008	6.9	0.95–50.115	0.056
TNM stage IV	55.189	7.558–402.996	< 0.001	42.134	5.746–308.933	< 0.001
GSE17538 validation (N = 200)
Seven-lncRNA risk score	1.945	1.317–2.873	< 0.001	1.905	1.206–3.008	0.0057
Age	0.98	0.962–0.999	0.043	0.989	0.968–1.01	0.312
Gender	0.75	0.441–1.276	0.289	0.848	0.481–1.493	0.567
TNM stage I	1.00(referent)			1.00(referent)
TNM stage II	5.177	0.668–40.132	0.116	4.313	0.552–33.69	0.163
TNM stage III	10.278	1.387–76.172	0.023	8.064	1.076–60.457	0.0423
TNM stage IV	49.435	6.615–369.41	< 0.001	40.052	5.299–302.762	< 0.001

Abbreviations: HR hazard ratio, CI confidence interval

^a In both univariable and multivariable Cox regression analyses, risk score and age were evaluated as continuous variables, and gender and TNM stage were evaluated as category variables

^bP < 0.05 was considered statistically significant in all analyses