Table 2.
Individuals | N | RRR | Lower | Upper | P value | Test for heterogeneity | P value for interaction | |||
---|---|---|---|---|---|---|---|---|---|---|
I2 | χ2 | P value | ||||||||
Unmarried vs. married | 7,659,086 | 15 | ||||||||
Age (years) | 0.74 | |||||||||
<60 | 775,733 | 7 | 0.82 | 0.70 | 0.95 | 0.01 | 63.10% | 16.24 | 0.01 | |
≥60 | 233,378 | 4 | 0.86 | 0.70 | 1.06 | 0.15 | 33.50% | 4.51 | 0.21 | |
Others | 6,649,973 | 4 | 0.94 | 0.82 | 1.07 | 0.34 | 0.00% | 2.83 | 0.42 | |
Location | 0.78 | |||||||||
Asia | 363,787 | 4 | 0.87 | 0.74 | 1.02 | 0.09 | 19.50% | 1.7 | 0.29 | |
Europe | 6,660,861 | 7 | 0.83 | 0.71 | 0.97 | 0.02 | 49.40% | 2.35 | 0.07 | |
America | 634,438 | 4 | 0.89 | 0.74 | 1.08 | 0.23 | 47.00% | 1.2 | 0.13 | |
Others | ||||||||||
Follow-up years | 0.30 | |||||||||
<10 | 631,422 | 8 | 0.86 | 0.77 | 0.96 | 0.01 | 44.30% | 12.57 | 0.08 | |
≥10 | 7,027,664 | 7 | 0.85 | 0.71 | 1.02 | 0.08 | 47.00% | 11.32 | 0.08 | |
Publication years | 0.60 | |||||||||
≤2000 | 389,351 | 4 | 0.84 | 0.63 | 1.12 | 0.22 | 50.60% | 6.07 | 0.11 | |
2001-2009 | 303,618 | 8 | 0.82 | 0.71 | 0.95 | 0.01 | 39.60% | 11.59 | 0.12 | |
≥2010 | 6,966,117 | 3 | 0.93 | 0.87 | 0.99 | 0.02 | 7.90% | 2.17 | 0.34 | |
Widowed vs. married | 7,654,572 | 14 | ||||||||
Age (years) | 0.03 | |||||||||
<60 | 915,181 | 7 | 0.90 | 0.80 | 1.01 | 0.07 | 54.20% | 13.11 | 0.04 | |
≥60 | 100,822 | 3 | 0.57 | 0.42 | 0.77 | <0.001 | 0.00% | 0.85 | 0.65 | |
Others | 6,638,569 | 4 | 1.00 | 0.99 | 1.02 | <0.001 | 0.00% | 0.72 | 0.87 | |
Location | 0.64 | |||||||||
Asia | 265,742 | 5 | 0.88 | 0.76 | 1.02 | 0.09 | 54.20% | 5.69 | 0.22 | |
Europe | 6,652,570 | 5 | 0.81 | 0.61 | 1.07 | 0.14 | 0.00% | 15.24 | <0.001 | |
America | 736,260 | 4 | 0.99 | 0.93 | 1.06 | 0.85 | 0.00% | 2.22 | 0.53 | |
Others | NA | |||||||||
Follow-up years | 0.34 | |||||||||
<10 | 611,167 | 8 | 0.84 | 0.73 | 0.98 | 0.03 | 55.30% | 15.66 | 0.03 | |
≥10 | 7,043,405 | 6 | 0.94 | 0.81 | 1.09 | 0.43 | 55.00% | 11.12 | 0.05 | |
Publication years | ||||||||||
≤2000 | 375,391 | 2 | 0.71 | 0.36 | 1.39 | 0.31 | 84.10% | 6.27 | 0.01 | 0.003 |
2001-2009 | 313,064 | 9 | 0.84 | 0.76 | 0.92 | <0.001 | 0.00% | 7.71 | 0.46 | |
≥2010 | 6,966,117 | 3 | 1.00 | 0.99 | 1.02 | 0.99 | 0.00% | 0.01 | 1.00 | |
Separated vs. married | 7,520,677 | 12 | ||||||||
Age (years) | 0.60 | |||||||||
<60 | 93,931 | 7 | 0.81 | 0.66 | 0.98 | 0.03 | 81.80% | 32.99 | <0.001 | |
≥60 | 6,649,973 | 1 | 0.57 | 0.18 | 1.76 | 0.33 | NA | 0 | NA | |
Others | 776,773 | 4 | 0.79 | 0.50 | 1.24 | 0.31 | 69.80% | 9.93 | 0.04 | |
Location | 0.75 | |||||||||
Asia | 262,237 | 4 | 0.62 | 0.44 | 0.89 | 0.01 | 25.40% | 4.02 | 0.26 | |
Europe | 6,525,566 | 5 | 0.77 | 0.57 | 1.04 | 0.08 | 88.10% | 33.71 | <0.001 | |
America | 732,874 | 3 | 0.97 | 0.83 | 1.13 | 0.68 | 61.70% | 5.23 | 0.07 | |
Others | NA | |||||||||
Follow-up years | 0.20 | |||||||||
<10 | 604,276 | 6 | 0.73 | 0.59 | 0.90 | <0.001 | 76.70% | 21.48 | <0.001 | |
≥10 | 6,916,401 | 6 | 0.93 | 0.76 | 1.15 | 0.50 | 65.20% | 14.36 | 0.01 | |
Publication years | 0.94 | |||||||||
≤2000 | 375,391 | 2 | 1.01 | 0.65 | 1.57 | 0.96 | 23.00% | 1.3 | 0.26 | |
2001-2009 | 179,169 | 7 | 0.72 | 0.59 | 0.87 | <0.001 | 34.20% | 9.12 | 0.17 | |
≥2010 | 6,966,117 | 3 | 0.89 | 0.80 | 1.00 | 0.05 | 80.20% | 10.12 | 0.01 | |
Never married vs. married | 7,511,483 | 10 | ||||||||
Age (years) | 0.20 | |||||||||
<60 | 767,579 | 5 | 0.89 | 0.81 | 0.97 | 0.01 | 22.40% | 5.16 | 0.3 | |
≥60 | 93,931 | 1 | 0.54 | 0.31 | 0.95 | 0.03 | NA | 0 | NA | |
Others | 6,649,973 | 4 | 0.99 | 0.97 | 1.02 | 0.59 | 0.00% | 0.95 | 0.8 | |
Location | 0.51 | |||||||||
Asia | 232,631 | 3 | 0.87 | 0.66 | 1.15 | 0.31 | 0.00% | 1.62 | 0.44 | |
Europe | 6,658,279 | 5 | 0.85 | 0.71 | 1.01 | 0.06 | 71.40% | 14.01 | 0.01 | |
America | 620,573 | 2 | 0.94 | 0.86 | 1.03 | 0.18 | 0.00% | 0.62 | 0.43 | |
Others | NA | |||||||||
Follow-up years | 0.47 | |||||||||
<10 | 447,064 | 3 | 0.93 | 0.83 | 1.04 | 0.07 | 40.20% | 3.34 | 0.19 | |
≥10 | 7,052,854 | 6 | 0.84 | 0.70 | 1.02 | 0.21 | 50.20% | 10.04 | 0.07 | |
Others | 11,565 | 1 | 1.44 | 0.59 | 3.50 | 0.42 | NA | 0 | NA | |
Publication years | 0.21 | |||||||||
≤2000 | 414,446 | 3 | 0.86 | 0.69 | 1.08 | 0.19 | 58.20% | 4.78 | 0.09 | |
2001-2009 | 130,920 | 4 | 0.77 | 0.61 | 0.98 | 0.03 | 0.00% | 2.55 | 0.59 | |
≥2010 | 6,966,117 | 3 | 0.99 | 0.97 | 1.01 | 0.38 | 0.00% | 1.95 | 0.38 |
Abbreviations: N number of studies; NA not available.