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Interaction fingerprint between distinct residues in D2R and MLS1547. (A) The 2D interaction diagram of D2R in complex with MLS1547. Green ball-and-stick: MLS1547. (B) The interaction fingerprint between residues in D2R and MLS1547. It represents the interaction frequency during the MD simulations. (C) Arrestin recruitment for D2R variants showing mutations on key residues predicted by MD simulations. All mutated receptors show noticeably decreased signaling.
