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. 2020 Jan 23;6(2):274–282. doi: 10.1021/acscentsci.9b01247

Figure 5.

Figure 5

Two different roles of Na+ in D2 receptor activation. Left panel: an allosteric Na+ (yellow sphere) stabilizes the inactive state of receptor. Blue ball-and-sphere: dopamine molecule. Right panel: an orthosteric Na+ enhances the activation of receptor via a coordinating interaction with both H3936.55 and agonist molecule MLS1547 (black ball-and-stick).