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. 2020 Feb 21;10:24. doi: 10.3389/fcimb.2020.00024

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Copyright © 2020 Wang, Guo, He, Gong and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation analysis of differential gut microbiota and metabolites. (A) Heatmap of correlation between microbial genus abundances and serum metabolites in positive ion mode (left) and in negative ion mode (right). Only significant correlations (p ≤ 0.05) are colored. Positive correlations are indicated in blue and negative correlations in red. (B) Metabolites were annotated into different metabolic pathways between the positive ion mode (left) and in negative ion mode (right) by KEGG enriched bubble chart based on KEGG. (C) Metabolic pathway map in CSU patients. Green solid circles are marked as annotated metabolites, and blue circles are marked as down-regulated differential metabolites.