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. 2020 Feb 21;10:170. doi: 10.3389/fonc.2020.00170

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Copyright © 2020 Jin, Liu, Liu, Li, Xu, He, Liu, Zhang and Ke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The restoration of miR-661 inhibition led to inhibition of apoptosis, and promoted glioma cell migration, invasion, and EMT mediated by hsa_circ_0088732 knockdown. LN229 and U87-MG cells were transfected with hsa_circ_0088732 siRNAs and/or an miR-661 inhibitor, respectively. (A,B) Cell apoptosis was detected by PI/Annexin V FITC and Hoechst 33258 staining (^*P < 0.05, ^**P < 0.01 vs. NC group; ^#P < 0.05 vs. siRNA group). (C–E) Cell migration and invasion capabilities were evaluated by Transwell assays. (F) The levels of E-cadherin, N-cadherin, and vimentin expression were determined by western blotting. NC: negative control, siRNA: hsa_circ_0088732 siRNAs, Inhibitor: miR-661 inhibitor.