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. 2020 Feb 21;10:170. doi: 10.3389/fonc.2020.00170

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Copyright © 2020 Jin, Liu, Liu, Li, Xu, He, Liu, Zhang and Ke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hsa_circ_0088732 inhibited apoptosis and accelerated the migration, invasion, and EMT of glioma cells via miR-661 and RAB3D. LN229 and U87-MG cells were transfected with miR-661 mimics, RAB3D, and hsa_circ_0088732, respectively. The cell apoptosis rates (A,B) and numbers of migrated (C,D) and invaded (C,E) cells were assessed (^**P < 0.01 vs. control group; ^#P < 0.05 vs. mimics + EV group; ^$P < 0.05 vs. mimics + RAB3D + pcDNA vector group). EV, overexpression vector; pcD, pcDNA3.1 plasmid; circ, hsa_circ_0088732. Western blot assays were performed to determine the levels of E-cadherin, N-cadherin, and vimentin expression in the transfected LN229 and U87-MG cells (F).