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. 2020 Jan 22;6(2):283–292. doi: 10.1021/acscentsci.9b01272

Figure 4.

Figure 4

Mechanistic investigations for catalytic phosphorylation of alcohols with PEP-K and TBAHS. (A) A reaction using 1.0 equiv of TBAHS produced O-sulfate 40. (B) A postulated mechanism for the formation of POS 41 from PEP-K and TBAHS. (C) Reactivity of POS 42 in the presence of varied amounts of PEP-K. (D) 31P NMR and MS spectra of the reaction mixtures for 42 + PEP-K (above) and TBAHS + PEP-K (below), respectively. In 31P NMR, the peak at 1.5 ppm is phosphoric acid and the peak at −3.0 ppm is PEP-K.