Table 2.
Discovery and Replication Association Analysis Results for the Five Signals Reaching Significance in the Discovery Genome-Wide Association Studies that Have Not Previously Been Reported as Associated with Idiopathic Pulmonary Fibrosis
| Chr | Pos | rsid | Locus | Major Allele | Minor Allele | MAF (%) | Discovery Meta-Analysis |
Replication
Meta-Analysis |
Meta-Analysis of Discovery and
Replication |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR [95% CI] | P Value | OR [95% CI] | P Value | OR [95% CI] | P Value | |||||||
| 3 | 44902386 | rs78238620 | KIF15 | T | A | 5.3 | 1.58 [1.37–1.83] | 5.12 × 10−10 | 1.48 [1.24–1.77] | 1.43 × 10−5 | 1.54 [1.38–1.73] | 4.05 × 10−14 |
| 7 | 1909479 | rs12699415 | MAD1L1 | G | A | 42.0 | 1.28 [1.19–1.37] | 7.15 × 10−13 | 1.29 [1.18–1.41] | 2.27 × 10−8 | 1.28 [1.21–1.35] | 9.38 × 10−20 |
| 8 | 120934126 | rs28513081 | DEPTOR | A | G | 42.8 | 0.82 [0.76–0.87] | 1.20 × 10−9 | 0.87 [0.80–0.95] | 0.002 | 0.83 [0.79–0.88] | 1.93 × 10−11 |
| 10 | 93271016 | rs537322302 | HECTD2 | C | G | 0.3 | 7.82 [3.77–16.2] | 3.43 × 10−8 | 1.75 [0.81–3.78] | 0.155 | 3.85 [2.27–6.54] | 6.25 × 10−7 |
| 20 | 62324391 | rs41308092 | RTEL1 | G | A | 2.1 | 2.12 [1.67–2.69] | 7.65 × 10−10 | 1.45 [1.08–1.94] | 0.012 | 1.82 [1.51–2.19] | 2.24 × 10−10 |
Definition of abbreviations: Chr = chromosome; CI = confidence interval; MAF = minor allele frequency; OR = odds ratio; Pos = position; rsid = reference SNP cluster ID.
The minor allele is the effect allele, and the MAF is taken from across the studies used in the discovery meta-analysis.