Table 3.
Summary of annual rates of decline in lung function for the Total Group, Steroid User and Steroid Naïve groups before and after NIV initiation
|
Total Group mean (95% CI) |
Difference (p value) |
Steroid Users mean (95% CI) |
Difference (p value) |
Steroid Naïve mean (95% CI) |
Difference (p value) |
||||
| Pre-NIV | Post-NIV | Pre-NIV | Post-NIV | Pre-NIV | Post-NIV | ||||
| FVC (l) | −0.062 (−0.09 to –0.03) |
−0.09 (−0.11 to –0.06) |
<0.001* | −0.02 (−0.06 to 0.02) |
−0.09 (−0.14 to –0.04) |
0.14 | −0.06 (−0.10 to –0.02) |
−0.10 (−0.15 to –0.05) |
<0.001* |
| FVC z-score | −0.72 (−0.79 to –0.64) |
−0.46 (−0.54 to –0.38) |
<0.001* | −0.56 (−0.70 to –0.42) |
−0.75 (−0.89 to –0.61) |
<0.001* | −0.74 (−0.86 to –0.63) |
−0.44 (−0.56 to –0.32) |
<0.001* |
| FVC % predicted | −7.90 (−8.72 to –7.09) |
−5.02 (−5.90 to –4.14) |
<0.001* | −6.40 (−7.98 to –4.83) |
−8.36 (−9.91 to –6.80) |
<0.001* | −8.15 (−9.37 to –6.92) |
−4.62 (−5.74 to –3.49) |
<0.001* |
See online supplementary table 2S for FEV1 data.
FEV, forced expiratory volume; FVC, forced vital capacity; NIV, non-invasive ventilation.