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IgE deficiency tilts M2 macrophage polarization in Apoe−/− mice after 12 weeks of an atherogenic diet. Intima iNOS+Mac-2+ M1 macrophages (A) and Arg-1+Mac-2+ M2 macrophages (B) were presented as number per section. Scale: 100 μm, inset: 30 μm. RT-PCR determined the mRNA levels of inflammation and macrophage polarization genes in the thoracic-abdominal aortas (C) and peritoneal macrophages (D). n=5~13 mice per group. All data are mean±SEM. *P<0.05, **P<0.01.
