IgE deficiency reduces obesity and insulin resistance and promotes MSRN gene expression in aorta and peritoneal macrophages in Apoe−/− mice after 12 weeks of an atherogenic diet. Body weight gain (A), epididymal adipose tissue, subcutaneous adipose tissue, brown adipose tissue, and liver weight (B), food intake (C), GTT (D), ITT (E), and plasma insulin levels (F) were detected after 12 weeks of an atherogenic diet feeding. RT-PCR analysis of MSRN genes in the thoracic-abdominal aortas (G) and peritoneal macrophages (H). n=10 mice per group. All data are mean±SEM. *P<0.05, **P<0.01, ***P<0.001.