Table 4.

Adjusted least squares means at each study visit by level of caregiver depression

		Low depression (0-1.75)	High depression (>1.75)	P values
Outcome	Week	Adjusted mean (95% CI)	Adjusted mean (95% CI)	Depression	Week	Depression × Week
KABC Mental Processing Index	0	78.94 (77.48,80.39)	76.26 (74.76,77.76)	0.41	<0.001	<0.001
	48	77.50 (76.14,78.87)	76.96 (75.45,78.46)
	96	78.08 (76.66,79.51)	80.28 (78.71,81.85)
BOT-2 Total	0	50.94 (49.87,52.02)	51.33 (50.21,52.45)	0.81	<0.001	<0.001
	48	52.34 (51.33,53.34)	51.12 (50.04,52.21)
	96	50.51 (49.54,51.48)	51.12 (50.07,52.17)
BRIEF BRI	0	50.49 (48.75,52.23)	55.39 (53.56,57.21)	<0.001	<0.001	<0.001
	48	47.94 (46.26,49.61)	54.23 (52.37,56.08)
	96	46.12 (44.58,47.66)	55.67 (53.80,57.54)
BRIEF MI	0	49.95 (48.19,51.71)	53.43 (51.57,55.29)	<0.001	<0.001	<0.001
	48	46.64 (44.99,48.28)	51.15 (49.38,52.93)
	96	44.46 (42.90,46.02)	52.66 (50.87,54.45)
BRIEF GEC	0	50.09 (48.29,51.89)	54.58 (52.68,56.48)	<0.001	<0.001	<0.001
	48	46.99 (45.29,48.70)	52.45 (50.57,54.33)
	96	44.85 (43.25,46.46)	54.07 (52.22,55.91)
TOVA ADHD	0	−0.19 (−0.64,0.26)	0.15 (−0.34,0.64)	0.39	<0.001	0.002
	48	0.83 (0.37,1.29)	0.33 (−0.14,0.81)
	96	1.00 (0.56,1.45)	0.77 (0.27,1.27)
TOVA D-Prime	0	86.41 (84.46,88.35)	86.20 (84.08,88.33)	0.14	<0.001	<0.001
	48	91.24 (89.24,93.23)	87.72 (85.61,89.84)
	96	90.46 (88.56,92.35)	91.20 (89.05,93.34)

Kauffman Assessment Battery Test for Children II (KABC -II); Bruininks-Oseretsky Test of Motor Proficiency 2 (BOT-2); Behavior Rating Inventory of Executive Function (BRIEF) Behavioral Regulation Index (BRI), Metacognition Index (MI), Global Executive Composite (GEC); Test of Variables of Attention (TOVA), Attention-Deficit/Hyperactivity Disorder (ADHD).

Number of observations varied by test and assessment time point. In week 48: KABC= 598, BOT-2= 600, BRIEF= 601, T0VA= 592. In week 96: KABC= 583, BOT-2= 585, BRIEF= 585, TOVA= 580.