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. Author manuscript; available in PMC: 2020 Jul 20.
Published in final edited form as: Nat Microbiol. 2020 Jan 20;5(3):486–497. doi: 10.1038/s41564-019-0655-7

Extended Data Fig. 9. Changes in transcriptional activity (KEGG modules) in complex microbial communities in response to NAE treatment.

Extended Data Fig. 9

Log2 relative expression is shown for bacterial families contributing to a selection of KEGG modules in samples from chemostats A and B treated with DMSO control, individual NAEs, a combination of all four NAEs (denoted as NAE-mix), or oleic acid (OA). Family-level relative expression values were computed at the species level, averaged over replicates, and then averaged within-family while weighting by species abundance. Unknown (“x”) values represent cases where a function’s DNA and/or RNA abundance were zero for a given stratification (resulting in non-finite log2 relative expression). Col_sort refers to the measure (treatment, time or chemostat used to order the metadata columns). Abbreviations: PEA, palmitoylethanolamide; OEA, oleoyl ethanolamide; LEA, linoleoyl ethanolamide; AEA, arachidonoyl ethanolamide.