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. Author manuscript; available in PMC: 2020 Jun 21.
Published in final edited form as: Mol Psychiatry. 2019 Aug 28;25(7):1526–1536. doi: 10.1038/s41380-019-0490-5

Figure 4. Estimated Depression Scores as a Function of Treatment and the Left Ventral Striatal (VS) Reward Expectancy (RE) Sub-index.

Figure 4.

Dark lines represent estimated Hamilton Rating Scale for Depression (HRSD) scores and cones represent 95% confidence intervals. Values were estimated from the primary multilevel statistical model at three levels of the left RE sub-index, 1 SD below the mean (Panel A), the mean (Panel B), and 1 SD above the mean (Panel C). Panel D depicts the estimated HRSD scores at Week-8 (y-axis) from across the full range of left RE sub-index scores in the sample (x-axis). The dotted vertical line represents the point below which the sertraline (SERT) and placebo (PBO) difference crosses the NICE threshold for a clinically significant difference (HRSD ≥ 3 points).