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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Neuroendocrinology. 2019 Aug 30;110(3-4):172–184. doi: 10.1159/000503006

Figure 2.

Figure 2.

Distinct roles of arcuate and AVPV kisspeptin neurons in regulating estradiol feedback and reproductive function. A, Knockdown of ERα in arcuate kisspeptin neurons did not alter LH-pulse frequency on estrus (left) but desensitized the LH response to kisspeptin and GnRH challenge. B, Knockdown of ERα in AVPV kisspeptin neurons blunted the proestrous (left) and estradiol-induced (right) surges. C and D, Knockdown of ERα in arcuate (C) but not AVPV (D) kisspeptin neurons alter reproductive cyclicity. Adapted from [119].