Figure 1.

General participant workflow. Each group formed their own approach to predicting phenotypes of the exomes, but there were some similarities across all submissions. All groups subset the exome into genes known to be involved in the phenotypes of interest, then made predictions based on the variants in those subset genes. Some groups generated scores for each individual based on burden of variants of a certain class. Others clustered the genotypes alone and segmented the clusters into predicted phenotypes.