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Domain architecture and structures of HPIV3 and RSV F. (A) Diagram of HPIV3 and RSV F with fusion peptide (FP), N-terminal (HRN) and C-terminal (HRC) heptad repeat, and transmembrane (TM) domains. Structures of pre-fusion (B, PDB:4MMV) and post-fusion (C, PDB:3RRR) conformations of RSV F. (D) Peptide sequences for HPIV3-HRC, RSV-HRC, VIQKI-I456F, and VIQKI-I454F/I456F (Phe-substitutionsv in red).
