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. Author manuscript; available in PMC: 2021 Feb 5.
Published in final edited form as: J Am Chem Soc. 2020 Jan 23;142(5):2140–2144. doi: 10.1021/jacs.9b11548

Figure 4.

Figure 4.

X-ray structures of (A) 6HB segment of RSV F in post-fusion conformation (PDB:3RRR) and co-crystal structures of (B) RSV-HRN+VIQKI-I456F (PDB:6OJ7) and (C) HPIV3-HRN+VIQKI-I454F/I456F (PDB:6O40). The phenylalanine-substituted VIQKI analogs adopt a binding mode similar to that of RSV-HRC. Colors correspond to RSV-HRN (salmon), HPIV3-HRN (orange), RSV-HRC (yellow), and VIQKI/VIQKI-I456F/VIQKI-I454F/I456F (green with Phe-substitutions in violet). Electrostatic potential maps at the binding site of (D) Phe488 (RSV F), (E) Phe456 (RSV-HRN+VIQKI-I456F), and (F) Phe456 (HPIV3-HRN+VIQKI-I454F/I456F) with anionic (red), neutral (gray), or positive (blue) charge density.