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Implied time scale plots for 200-state MSMs of (a) GTT WW domain and (b) K12M NTL9(1–39) and for 1000-state MSMs of (c) GTT WW domain and (d) K12M NTL9(1–39). Uncertainties (shaded areas) for GTT and NTL9 were estimated using 5-fold and 8-fold leave-one-out bootstraps, respectively. The dotted vertical line marks the lag time of 100 ns chosen to construct the MSMs.
