Table 1.
Clinical characteristics of enrolled patients.
| Age and vital signs | NO treated (N = 39)a | Placebo treated (N = 39)a | ||
|---|---|---|---|---|
| Mean | SD | Mean | SD | |
| Age (years) | 55 | 15 | 59 | 16 |
| Body mass index (kg/mˆ2) | 36 | 12 | 33 | 11 |
| Heart rate (beats/min) | 86 | 12 | 93 | 13 |
| Systolic blood pressure (mm Hg) | 125 | 20 | 127 | 20 |
| Pulse oximetry (%) | 97 | 3 | 96 | 6 |
| Patient features and past medical history | N | % | N | % |
| Female gender | 21 | 54% | 20 | 51% |
| Caucasian race | 28 | 72% | 21 | 54% |
| Creatinine > 1.7 mg/dL | 2 | 6% | 1 | 3% |
| Hemoglobin < 10.0 g/dL | 9 | 26% | 5 | 14% |
| Surgery in past 4 weeks | 7 | 18% | 4 | 10% |
| Trauma in past 4 weeks | 4 | 10% | 5 | 13% |
| Coronary artery disease | 3 | 8% | 5 | 13% |
| Heart failure | 6 | 15% | 1 | 3% |
| Chronic obstructive pulmonary disease | 7 | 18% | 4 | 10% |
| Prior venous thromboembolism | 10 | 26% | 12 | 31% |
| Active cancer | 3 | 8% | 5 | 13% |
| Connective tissue disease | 6 | 15% | 7 | 18% |
| Post partum (within 4 weeks) | 1 | 3% | 1 | 3% |
| Never smoked | 25 | 64% | 20 | 51% |
| Markers of RV strain | Median or proportion | 1st-3rd quartile or percentage | Median or proportion | 1st-3rd quartile or percentage |
| Troponin concentration (pg/mL) | 23 | 12–71 | 51 | 18–101 |
| Brain natriuretic peptide (pg/mL) | 206 | 83–386 | 234 | 84–556 |
| Right ventricular systolic pressure (mm Hgb) | 54.5 | 50–62 | 50 | 47–52.5 |
| Right ventricular/Left ventricular ratio | 1.12 | 0.89–1.69 | 1.10 | 0.85–1.68 |
| Right ventricular dilation (> 43 mm) on echocardiography | 14/24 | 58% | 13/26 | 50% |
| Right ventricular hypokinesis on echocardiography | 15/24 | 63% | 20/26 | 77% |
a
These data are for enrolled patients; one patient in each group withdrew after enrollment.
b
Estimated from equation Vˆ2*4 + 10 mm Hg where V = tricuspid regurgitant jet velocity (meters/second).