Table 2.

Clinical Laboratory Values Associated with Fatigue

Author/Yea	Number of Participants	Kt/V	Serum Creatinine	Parathyroid Hormone	Anemia	Albumin	Markers of Inflammation	Design	Fatigue Measure	Strengths	Weaknesses
Bossola, Luciani, & Tazza, 2009	62	N/A	Yes (↓)	No	N/A	Yes (↓)	Yes: IL-6 (↑)	Cross-sectional	SF-36	Comparison of fatigue and non-fatigued participants on HD	Limited sample size Cross-sectional
Bossola, Stasio, Antocicco, & Tazza, 2013	68	No	No	No	N/A	No	No	Cross-sectional	Six Yes or No questions based on the Hardy and Studenski model	All patients on HD received erythropoietin to maintain hemoglobin levels between 11- 12 g/L and treated to target PTH and albumin levels and Kt/V according to the guidelines	Dichotomous fatigue measure Limited sample size Cross-sectional
Jhamb, et al., 2009	917 (705 included in adjusted models)	No	Yes (↓)	N/A	No	Yes (↓)	Yes: C-reactive protein (↑) and IL-6 (↑)	Longitudinal	SF-36 vitality scale	Large sample size Included patients on HD and PD Longitudinal	Fatigue was only measured at baseline and one year on dialysis through vitality scores
Liu, 2006	119	No	N/A	N/A	No	No	N/A	Cross-sectional Correlational	Fatigue Assess Scale	Large sample size of individuals on HD	Cross-sectional
Wang et al., 2016	345	Yes Kt/V < 1.2	Yes(↓)	N/A	No	No	N/A	Cross-sectional	FACIT-Fatigue	Participants recruited from two HD centers Large sample size	Cross-sectional Only examined a few potential variables for fatigue
Williams, Crane, & Kring, 2007	36	N/A	N/A	N/A	No	No	N/A	Cross-sectional Descriptive Correlational	Fatigue Visual Analog Scale	Homogenous sample of only African American women on HD.	Limited sample size Analyzed only African American women.

Notes: N/A = not available, ↑ = increased, ↓ = decreased.