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. Author manuscript; available in PMC: 2021 Jan 3.
Published in final edited form as: Circ Res. 2019 Nov 8;126(1):60–74. doi: 10.1161/CIRCRESAHA.119.315180

Figure 6. Kinetic modeling of phosphoglucose isomerase inhibition reveals redirection of glycolytic intermediates into the pentose phosphate pathway.

Figure 6.

(A) Pentose phosphate pathway expansion of CardioGlyco. (B-C) Predicted metabolite concentrations (B) and flux rates (C) in response to PGI inhibition (20% activity). PFK activity was not changed. Extracellular glucose supply was set to 5.5 mmol/L during the simulations. (D) Comparison of G6PDH flux rate at 20% and 100% PGI activity. Simulations indicated that PGI inhibition promotes G6P accumulation and an increased G6PDH flux rate.