Table 4.

General recommendation strength of thiazide diuretics preventing recurrent renal stones

Factor	Decision making
Quality of the evidence (The higher the quality of the evidence, the more likely a strong recommendation is warranted.)	Low
Balance of benefits versus harms and burdens (The larger the difference between the benefits and harms, the more likely a strong recommendation is warranted. The smaller the net benefit and the lower the certainty for that benefit, the more likely a conditional recommendation is warranted.)	Benefits and harms are balanced
Values and preferences (The greater the variability or uncertainty in values and preferences, the more likely a conditional recommendation is warranted.)	Major variability
Resource use (The higher the costs of an intervention, that is, the more resources consumed, the more likely a conditional recommendation is warranted.)	Moderate resource-intensive
Overall recommended strength	Low ↑?