FIG 1.

(A) Leisure-time physical activity (metabolic equivalent task [MET]–hours/week) and risk of cancer sites with strong evidence of association. (B) Association between leisure-time physical activity (MET hours/week) and cancer sites with moderate or lower evidence of association. Analysis is adjusted for entry age, sex, race, education, smoking, and alcohol intake. For breast and endometrial cancer, we also adjusted for postmenopausal hormone treatment, age at menarche and menopause, parity, and oral contraceptive use. Restricted cubic splines were fit with 3 knots placed at the 5th, 50th, and 95th percentiles of physical activity. Shaded area indicates recommended amounts of physical activity. Cancer sites were judged as strong evidence of association by the 2018 US Physical Activity Guidelines Advisory Committee.³