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. 2020 Feb 18;9(1):1725285. doi: 10.1080/20013078.2020.1725285

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Methylation state of the loci encoding miRNAs showing a differential expression in SEN compared with CON cells. (a) Box plots showing the log2 B value fold change in SEN vs CON cells at CpG loci located within the coding regions of selected miRNA. Yellow: over-methylated CpG sites (median value); Blue: under-methylated CpG sites (median value). (b) PCA of DNA methylation values in CON and SEN triplicates, considering only the InfiniumEPIC probes mapping within 2000 bp upstream and downstream the miRNAs differentially expressed in SEN vs CON. The percentage of variance explained by the first and the second principal components is reported in brackets. (c) Figure summarising expression levels and methylation state of miRNAs showing a differential expression in SEN cells. MiRNAs showing expression concordant with the methylation state are enclosed in black lines. MiRNAs commonly de-regulated in SEN cells and their cognate sEVs and lEVs are highlighted in bold. Significantly methylated or unmethylated miRNAs are marked with (*).