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. Author manuscript; available in PMC: 2020 Feb 28.
Published in final edited form as: Cancer Lett. 2018 Aug 2;439:91–100. doi: 10.1016/j.canlet.2018.07.034

Fig. 4. Duloxetine (Dul) inhibited the growth of GL261 gliomas.

Fig. 4.

(A) Representative histology (left) and tumor volume measurements (right) demonstrating inhibition of i.c. GL261 tumor growth with Dul. Mice were treated with Dul a day after tumor implantation. Fourteen days later, brains were harvested and the largest tumor area was used for size calculations. (n =5 mice/group ± SD). (B) Kaplan–Meier survival curve of tumor-bearing mice treated with daily vehicle or Dul for 14 days (n = 6 mice/group). Animals demonstrating signs of elevated intracranial pressure were euthanized and tumor presence confirmed by histology. *: p < 0.05, **: p < 0.01 compared to control group. MS: median survival. Results are representative of two separate experiments.