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Nrf2 inhibits neuron damage around amyloid plaques. (A) Immunofluorescence analysis of Tuj1 and Aβ in the cerebral cortices of 11-month-old mice. Yellow arrows indicate the decreased Tuj1-positive staining around amyloid plaques. White arrows indicate retained neurons. (B and C) TUNEL assay and Hoechst 33342 straining in the cerebral cortices and the hippocampi of 11-month-old mouse brains (B), with rat mammary tissue as a positive control (C). Scale bars: 50 μm (A) and 100 μm (B and C).
