FIG 2.

The activity of specific promoter regions of Dbp is affected by hnRNP K. (A) Along with WT(Short) promoter activity (the region contained 564 bp from the TSS), the level of WT(Long) promoter activity (the region contained 1,500 bp from the TSS) was similarly downregulated by the lack of hnRNP K, while that of a promoterless vector was not (n = 3; n.s., not significant; *, P < 0.05 by two-way ANOVA followed by Sidak’s multiple-comparison test). (B) Representative detrended bioluminescence recordings of WT(Short):LUC and WT(Long):LUC were measured with luciferase reporter-transfected NIH 3T3 cells after dexamethasone synchronization during knockdown of hnRNP K, which showed a decrease in the amplitude levels of WT(Short):LUC and WT(Long):LUC. sihnK, sihnRNP K. (C) Knockdown of hnRNP K decreased the levels of P3, P4, P6, and WT(Short) promoter activity (n = 3; n.s., not significant; *, P < 0.05 by two-way ANOVA followed by Sidak’s multiple-comparison test). Error bars indicate SEM.