TABLE 1.

Summary of Viral-Mediated Six3 Misexpression on Eye Morphogenesis

Injection	Virus	Harvest	No. of survivors	No. with phenotypes	% with abnormalities
Stage 10	RCAS(A)	E12	48	0
		E16	4	1	1.6
		E18	8	0
	Six3	E12	31	24
		E16	3	2	78.0
		E18	7	6
	Six3.V-E	E12	26	2	7.7
	Six3.ΔS	E12	26	12	46.1
Stage 17	RCAS(A)	E16	13	0	0
	Six3	E16	8	6	75.0

Note. Viruses were injected at stage 10 into the neural tube or at stage 17 into the periocular mesenchyme and further incubated at 38°C until harvesting. Ocular abnormalities, primarily corneal protrusion, were scored by comparing the external appearance of Six3 viruses infected eyes with RCAS(A) control virus infected eyes at a given stage. Percentages of abnormality represent embryos harvested between E12 and E18