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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Neurobiol Learn Mem. 2019 Dec 9;167:107132. doi: 10.1016/j.nlm.2019.107132

Figure 4. Acquisition of trace fear conditioning increases intrinsic excitability of dorsal hippocampal CA1 pyramidal neurons.

Figure 4.

(A) Representative traces of the post-burst AHP illustrating that DH CA1 neurons from good learners had smaller AHPs compared to those from poor learners, pseudoconditioned, chamber-exposed, and naïve rats. Scale bar, 2 mV, 100 ms. (B) Plot showing the time course of the post-burst AHP amplitude as a function of training condition. Neurons from good learners had a significantly smaller AHP compared to all other groups when measured at 0.1 – 0.8 s following current offset (p < 0.05). (C) AP output of DH CA1 neurons in response to a prolonged 1 s current injection. Notice that CA1 pyramidal neurons from good learners fired more APs than did CA1 neurons from poor learners, pseudoconditioned, chamber-exposed, or naïve rats. Scale bar, 20 mV, 100 ms. Abbreviations: dorsal hippocampus (DH); afterhyperpolarization (AHP); action potential (AP). Adapted from Song et al., 2012.