Impact of detection thresholds on sensitivity, the number of false-positives, and the positive predictive value (PPV). Versions A, B, C, D without detection thresholds (A0, B0, C0, D0) and with thresholds of 5 mm3 (A5, B5, C5, D5), 6 mm3 (A6, B6, C6, D6), and 7 mm3 (A7, B7, C7, D7). Depicted as bars are the FPs/case; depicted as diamonds are the sensitivities. PPV is shown below the diagrams for each model. The asterisk indicates P < .05; double asterisks, P = .001; triple asterisks, P < .001.