Fig. 2.

Liver cancers were less inflamed than non-tumorous livers. (a) The expression levels of immune-related genes and multigene signatures in tumor and non-tumorous liver. Samples are ordered by hierarchical clustering of gene expression levels. NBNC, negative for both HBV and HCV; HCC, hepatocellular carcinoma; ICC, intrahepatic cholangiocarcinoma; cHCC/ICC; combined HCC-ICC. (b, c) Immune gene expression signatures in matched tumor and non-tumorous liver. P-values were computed using Wilcoxon signed-rank test. (b) Cytolytic activity. (c) Immune cell signatures. (d) The fraction of Sia's immune class in tumor and non-tumorous liver.