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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Prog Biophys Mol Biol. 2019 Aug 29;154:3–10. doi: 10.1016/j.pbiomolbio.2019.07.004

Figure 2.

Figure 2.

A. Two long wavelength, electrochromic voltage-sensitive dyes Di-4-ANBDQBS and Di-4-ANEQ(F)PTEA are used to record electrical signal propagation from live pig hearts (open chest, anaesthetized). Two time multiplexed excitation light sources at the blue and red edge of the dyes’ excitation spectra are used to capture raw signals “Numerator” and “Denominator”, respectively. Only after taking the ratio do the true electrical signals, free of otherwise overwhelming motion artifacts, appear. B. Snapshots of normalized voltage fluorescence intensity maps following point stimulation. Reprinted with modification from original (Lee et al., 2019, Fig. 5).