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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Hepatology. 2020 Jan 24;71(4):1228–1246. doi: 10.1002/hep.30921

Figure 1. Hepatocyte-specific inactivation of hnRNPU exacerbates CDAHFD-induced NASH.

Figure 1.

(A) Pie chart depicting NASH regulation of the liver genes containing binding sites for hnRNPU.

(B) Plasma ALT and AST levels.

(C) H&E and Sirius red staining of liver sections from mice fed CDAHFD for three weeks. Arrowheads indicate infiltrated immune cells. Scale bars: 200 μm.

(D) F4/80 immunofluorescence staining of liver sections. Scale bars: 100 μm.

(E) DCN immunofluorescence staining of liver sections. Scale bars: 100 μm.

(F) Quantification of immune cell infiltration, collagen deposition, and DCN- and F4/80-positive areas. Data in (B) and (F) represent mean ± SEM (Ctrl n=8; LKO n=6). **P<0.01, Ctrl vs. LKO, two-tailed unpaired Student’s t-test.