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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Hepatology. 2020 Jan 24;71(4):1228–1246. doi: 10.1002/hep.30921

Figure 5. Induction of TrkB-T1 expression in mouse NASH.

Figure 5.

(A) UCSC genome browser view of Ntrk2 liver RNA-seq reads from mice fed chow or AMLN diet (n=3).

(B) qPCR analysis of TrkB isoforms in the liver from mice fed chow or AMLN diet (n=3) using isoform-specific primers. Data represent mean ± SEM. *P<0.05, **P<0.01; AMLN vs. chow, two-tailed unpaired Student’s t-test.

(C) Immunoblots of total liver lysates from chow or ALMN diet-fed mice.

(D) Correlation of liver TrkB-T1 mRNA expression with plasma ALT and AST in a cohort of AMLN diet-fed WT mice exhibiting different severity of liver injury (n=15).

(E) Representative TrkB immunofluorescence in chow and AMLN diet-fed mouse livers. Arrowheads indicate HNF4α-positive hepatocytes. Scale bars: 100 μm