Fig. 5.

Blocking integrin αvβ6 could prevent morphologic changes and the increase of MMP-2 and -9 secretion induced by P. aeruginosa’s LPS. Cell morphologic change was ameliorated by 10D5 and SB431542 (a). ELISA showed that the secretion of active MMP-2 and -9 was significantly increased by P. aeruginosa’s LPS which could be attenuated by integrin αvβ6–blocking antibody 10D5 as well as specific inhibitor of TGF-β1-Smad2/3 signaling, inhibitor SB431542 (b). The data represent the mean ± SEM, n = 3. *p < 0.05 versus Con, #p < 0.05 versus LPS