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. 2020 Feb 28;11:1119. doi: 10.1038/s41467-020-14801-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Blocking CORT synthesis during adversity-rearing prohibited expression of atypical behavior during a 30-min social behavior test outside of the nest. b Blocking CORT synthesis during SSP prevented expression of atypical attachment behavior during reunion with the mother. Ninety minutes before SSP, pups received the CORT synthesis inhibitor metyrapone (50 mg/kg) or saline. c In an internal replication of Exp. 1, saline-treated, adversity-reared pups failed to exhibit decreased beta and gamma oscillations upon reunion with the mother; this maternal regulation was restored if they were administered metyrapone before the test. Bars represent mean ± SEM of power collapsed into frequency bands. d CORT inhibition in maltreated pups restored control-like coupling during reunion with the mother in the rSSP. Dashed line = no change from baseline; + indicates mean significantly different from baseline (1). *p < 0.05, ANOVA. Source data are provided as a Source Data file.