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. 2020 Feb 28;10:3715. doi: 10.1038/s41598-020-60431-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Destabilization of ANG variants correlates with longer ALS duration. Spearman’s Coefficient (p value 0.016) and Kendall Tau’s coefficient (p value 0.021) were used for analyzing correlation. Kaplan-Meier survival analysis was performed and the statistical significance of differences in survival between the categories was evaluated using Log-rank (p value 0.072), Breslow (p value 0.086), and Tarone-ware (p value 0.077) tests. A significance level of 0.05 was used. (a) Scatter plot representing correlation between thermal destabilization and disease duration. Sizes of points are proportional to number of cases. (b) Kaplan-Meier curves illustrating differences in ALS onset between patients with ANG variants with ∆∆G less than or equal to −1 kcal/mol and variants with ∆∆G greater than −1 kcal/mol.