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. 2020 Feb 28;10:3738. doi: 10.1038/s41598-020-60623-0

Table 4.

Summary of inhibitory activity of nisin P and A.

Strain Activity
nisin P
Activity
nisin A
MIC
nisin P
MIC
nisin A
S. enterica LT2
E. coli ATCC 25922
C. sakazakii NCTC 11467
C. perfringens NCTC 3110a
L. innocua NCTC 11288
L. bulgaricus LMG 6901 +++ +++ 0.01 μM 0.0005 μM
L. monocytogenes 3564 ++
E. faecium 4955 ++ +++ 0.265 μM 0.1 μM
E. faecalis LM1 ++ 6.5 μM
E. faecalis LM4 ++ 6.5 μM
P. aeruginosa 2064 APC
S. aureus 7016 ++ +++ 0.531 μM 0.05 μM
S. capitis 20G ++ +++ 8.5 μM 0.812 μM
S. simulans 2B10 ++ +++ 0.531 μM 0.325 μM
S. epidermidis 99 + +++ 34 μM 0.812 μM
L. gallinarum Lac43 + ++ 8.5 μM 0.812 μM
L. frumenti Lac53 +++ +++ 1.06 μM 0.27 μM
L. reuteri Lac54 + ++ 8.5 μM 0.812 μM
L. paracasei LacR1 ++ +++ 17 μM 1.62 μM
L. plantarum Lac 29 +++ +++ 1.06 μM 0.1 μM
L. mucosae Lac28 +++ +++ 1.06 μM 0.54 μM
L. reuteri Lac 56 + ++ 69 μM 3.25 μM

aC. perfringens NCTC 3110 has usually been reported to be sensitive to nisin A.

−, No activity; +, 1 mm radius inhibition zone; ++, 1–5 mm radius inhibition zone; +++, >5 mm inhibition zone.