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. 2020 Feb 28;11(2):155. doi: 10.1038/s41419-020-2338-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a LDLRAD4 expression was distinctly negatively correlated with SNAI1 based on expression data from GSE39582 (Y = −0.1344*X + 5.901, p = 0.0024). b LncRNA LDLRAD4-AS1 expression was distinctly positively correlated with SNAI1 based on expression data from GSE39582 (Y = 0.1868*X + 4.539, p = 0.0269). c Snail increased with lncRNA LDLRAD4-AS1 overexpression and decreased with lncRNA LDLRAD4-AS1 silencing using western blotting, and E-cadherin changed accordingly. Also, snail decreased with LDLRAD4 overexpression and increased with LDLRAD4 silencing using western blotting, and E-cadherin changed accordingly. d The images of H&E staining, IHC for LDLRAD4 and snail in xenografts were shown. e A proposed model for illustrating the function and mechanism of lncRNA LDLRAD4-AS1 in CRC EMT and metastasis.