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. 2020 Feb 28;10:3760. doi: 10.1038/s41598-020-60638-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of genes associated with Hlf over-expression in dentate gyrus neurons of adult male mice. (a) The representative expression pattern of EGFP reporter expression after AAV-HLF injection in the ipsilateral hippocampus. Scalebar = 400 μm (b) Relative mean expression (±SD) of PAR bZIP TFs and inflammatory cytokines after AAV-HLF injection. The t-test was performed to evaluate significance. ***p < 0.001. (c) Co-localization of EGFP reporter expression with immunohistological staining specific for neurons (NeuN), astrocytes (GFAP) and microglia (Iba1). White arrows show co-localization of HLF-EGFP reporter with neuronal NeuN staining. Scalebar = 50 μm. (d) Heatmap shows the z-score from the transformed counts of each individual sample replicate, for all differentially expressed genes. (e) Summary of enrichment for GO molecular function and (f) Biological process. Figures were created using Adobe Illustrator version 23.1.1. www.adobe.com/Illustrator, R version 3.4.3.; https://www.R-project.org and GraphPad Prism version 8.3.1 for macOS, www.graphpad.com.