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. 2020 Feb 28;10:3760. doi: 10.1038/s41598-020-60638-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relative mean expression (±SD) of clock genes (Clock, Bmal1, Npas2, Per1, Per2, Per3, Cry1, Cry2, Rev-erb-α and Rorc) in ipsilateral dorsal hippocampus at 1, 6 and 14 days post injection (dpi) of KA in adult male mice. ZT0, ZT6, ZT12 and ZT18 (ZT = Zeitgeber time, ZT0 lights on, ZT12 lights off). White and black circles represent individual values for control and KA groups, respectively. The t-test with multiple-testing correction was performed to evaluate significance between control and KA groups. *p < 0.05. Figures were created using GraphPad Prism version 8.3.1 for macOS, www.graphpad.com.